Ontology highlight
ABSTRACT:
SUBMITTER: Torke S
PROVIDER: S-EPMC7498502 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Torke Sebastian S Pretzsch Roxanne R Häusler Darius D Haselmayer Philipp P Grenningloh Roland R Boschert Ursula U Brück Wolfgang W Weber Martin S MS
Acta neuropathologica 20200806 4
Anti-CD20-mediated B-cell depletion effectively reduces acute multiple sclerosis (MS) flares. Recent data shows that antibody-mediated extinction of B cells as a lasting immune suppression, harbors the risk of developing humoral deficiencies over time. Accordingly, more selective, durable and reversible B-cell-directed MS therapies are needed. We here tested inhibition of Bruton's tyrosine kinase (BTK), an enzyme centrally involved in B-cell receptor signaling, as the most promising approach in ...[more]