Ontology highlight
ABSTRACT:
SUBMITTER: Mok S
PROVIDER: S-EPMC7505969 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Mok Stephanie S Al Habyan Sara S Ledoux Charles C Lee Wontae W MacDonald Katherine N KN McCaffrey Luke L Moraes Christopher C
Nature communications 20200921 1
Local tissue mechanics play a critical role in cell function, but measuring these properties at cellular length scales in living 3D tissues can present considerable challenges. Here we present thermoresponsive, smart material microgels that can be dispersed or injected into tissues and optically assayed to measure residual tissue elasticity after creep over several weeks. We first develop and characterize the sensors, and demonstrate that internal mechanical profiles of live multicellular sphero ...[more]