Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity.
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ABSTRACT:
SUBMITTER: Koch C
PROVIDER: S-EPMC7507517 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity.
Koch Claudia C Kuske Andra A Joosse Simon A SA Yigit Gökhan G Sflomos George G Thaler Sonja S Smit Daniel J DJ Werner Stefan S Borgmann Kerstin K Gärtner Sebastian S Mossahebi Mohammadi Parinaz P Battista Laura L Cayrefourcq Laure L Altmüller Janine J Salinas-Riester Gabriela G Raithatha Kaamini K Zibat Arne A Goy Yvonne Y Ott Leonie L Bartkowiak Kai K Tan Tuan Zea TZ Zhou Qing Q Speicher Michael R MR Müller Volkmar V Gorges Tobias M TM Jücker Manfred M Thiery Jean-Paul JP Brisken Cathrin C Riethdorf Sabine S Alix-Panabières Catherine C Pantel Klaus K
EMBO molecular medicine 20200715 9
Functional studies giving insight into the biology of circulating tumor cells (CTCs) remain scarce due to the low frequency of CTCs and lack of appropriate models. Here, we describe the characterization of a novel CTC-derived breast cancer cell line, designated CTC-ITB-01, established from a patient with metastatic estrogen receptor-positive (ER<sup>+</sup> ) breast cancer, resistant to endocrine therapy. CTC-ITB-01 remained ER<sup>+</sup> in culture, and copy number alteration (CNA) profiling s ...[more]
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