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Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease.


ABSTRACT: BACKGROUND:Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD). RESULTS:A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p < .05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p = 1.05 × 10-25 , 3.54 × 10-25 , and 2.74 × 10-7 , respectively). Multivariate analysis showed LGALS3 rs2274273 and rs4644 genotypes contributing to 20.8% variation of galectin-3 levels. However, there was no association between LGALS3 genotypes and other inflammatory marker levels. CONCLUSIONS:Our data showed strong genetic determinants of galectin-3 levels in patients with CAD. The galectin-3 levels, but not LGALS3 genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin-3 in the pathogenesis of chronic inflammatory disorders.

SUBMITTER: Liao YH 

PROVIDER: S-EPMC7507567 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease.

Liao Yu-Huang YH   Teng Ming-Sheng MS   Juang Jyh-Ming J JJ   Chiang Fu-Tien FT   Er Leay-Kiaw LK   Wu Semon S   Ko Yu-Lin YL  

Molecular genetics & genomic medicine 20200623 9


<h4>Background</h4>Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD).<h4>Results</h4>A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metallopro  ...[more]

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