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Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity.

ABSTRACT: The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just how important is IFN-I to antiviral defence in humans? The recent discovery of genetic defects of IFN-I signalling illuminates this and other questions of IFN biology, including the role of the mucosa-restricted type III IFNs (IFN-III), informing our understanding of the place of the IFN system within the concerted antiviral response. Here we review monogenic lesions of IFN-I signalling pathways and summarise the organising principles which emerge.

SUBMITTER: Duncan CJA

PROVIDER: S-EPMC7508017 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity.

Duncan Christopher J A CJA Randall Richard E RE Hambleton Sophie S

Trends in genetics : TIG 20200922 1

The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just how important is IFN-I to antiviral defence in humans? The recent discovery of genetic defects of IFN-I signalling illuminates this and other questions of IFN biology, including the role of the mucosa- ...[more]

PMID: 32977999

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