Ontology highlight
ABSTRACT:
SUBMITTER: Cao L
PROVIDER: S-EPMC6893850 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Cao Lili L Yang Guang G Gao Shandian S Jing Chunxia C Montgomery Ruth R RR Yin Yuxin Y Wang Penghua P Fikrig Erol E You Fuping F
Science signaling 20190319 573
Precise control of interferons (IFNs) is crucial to maintain immune homeostasis. Here, we demonstrated that homeodomain-interacting protein kinase 2 (HIPK2) was required for the production of type I IFNs in response to RNA virus infection. HIPK2 deficiency markedly impaired IFN production in macrophages after vesicular stomatitis virus (VSV) infection, and HIPK2-deficient mice were more susceptible to lethal VSV disease than were wild-type mice. After VSV infection, HIPK2 was cleaved by active c ...[more]