Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XX
PROVIDER: S-EPMC7508854 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Zhang Xin-Xing XX Brantley Shelby L SL Corcelli Steven A SA Tokmakoff Andrei A
Communications biology 20200922 1
Understanding the dynamic interactions of ligands to DNA is important in DNA-based nanotechnologies. By structurally tracking the dissociation of Hoechst 33258-bound DNA (d(CGCAAATTTGCG)<sub>2</sub>) complex (H-DNA) with T-jump 2D-IR spectroscopy, the ligand is found to strongly disturb the stability of the three C:G base pairs adjacent to A:T the binding site, with the broken base pairs being more than triple at 100 ns. The strong stabilization effect of the ligand on DNA duplex makes this obse ...[more]