Ontology highlight
ABSTRACT:
SUBMITTER: Jain N
PROVIDER: S-EPMC7509871 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Jain Neeraj N Singh Satishkumar S Laliotis Georgios G Hart Amber A Muhowski Elizabeth E Kupcova Kristyna K Chrbolkova Tereza T Khashab Tamer T Chowdhury Sayan Mullick SM Sircar Anuvrat A Shirazi Fazal F Singh Ram Kumar RK Alinari Lapo L Zhu Jiangjiang J Havranek Ondrej O Tsichlis Philip P Woyach Jennifer J Baiocchi Robert R Samaniego Felipe F Sehgal Lalit L
Blood advances 20200901 18
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma; 40% of patients relapse after a complete response or are refractory to therapy. To survive, the activated B-cell (ABC) subtype of DLBCL relies upon B-cell receptor signaling, which can be modulated by the activity of Bruton tyrosine kinase (BTK). Targeting BTK with ibrutinib, an inhibitor, provides a therapeutic approach for this subtype of DLBCL. However, non-Hodgkin lymphoma is often resistant to ibrutini ...[more]