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Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases.

ABSTRACT: This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore-forming activity on cell membranes and are executors for programmed cell death with cytokines release, and play roles in cancers and inflammation-driven diseases. Therefore, they can be used as potential therapeutic targets to treat related diseases.

SUBMITTER: Wu D

PROVIDER: S-EPMC7511492 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases.

Wu Danbin D Chen Yefei Y Sun Yingxin Y Gao Qing Q Yu Bin B Jiang Xijuan X Guo Maojuan M

Journal of cell communication and signaling 20200331 3

This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore-forming activity on cell membranes and are executors for programmed cell death with cytokines release, and play roles in cancers and inflammation-driven diseases. Therefore, they can be used as potential therapeutic targets to treat related diseases. ...[more]

PMID: 32236886

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