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Pyroptosis: A promising therapeutic target for noninfectious diseases.

ABSTRACT: Pyroptosis, which is characterized by gasdermin family protein-mediated pore formation, cellular lysis and the release of pro-inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens-induced infection. However, emerging evidence indicates that pyroptosis also contributes to sterile inflammation. In this review, we will first illustrate the biological process of pyroptosis. Then, we will focus on the pathogenic effects of pyroptosis on multiple noninfectious disorders. At last, we will characterize several specific pyroptotic inhibitors targeting the pyroptotic signalling pathway. These data demonstrate that pyroptosis plays a prominent role in sterile diseases, thereby providing a promising approach to the treatment of noninfective inflammatory disorders.

SUBMITTER: Li T

PROVIDER: S-EPMC8560609 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Pyroptosis: A promising therapeutic target for noninfectious diseases.

Li Tong T Zheng Guangjuan G Li Ben B Tang Lipeng L

Cell proliferation 20210929 11

Pyroptosis, which is characterized by gasdermin family protein-mediated pore formation, cellular lysis and the release of pro-inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens-induced infection. However, emerging evidence indicates that pyroptosis also contributes to sterile inflammation. In this review, we will first illustrate the biological process of pyroptosis. Then, we will focus on the pathogenic effects of pyroptosis on multiple noninfecti ...[more]

PMID: 34590363

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