Ontology highlight
ABSTRACT:
SUBMITTER: Zhen L
PROVIDER: S-EPMC7515978 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Zhen Lixiao L Zhao Qian Q Lü Jinhui J Deng Shengqiong S Xu Zhen Z Zhang Lin L Zhang Yuzhen Y Fan Huimin H Chen Xiongwen X Liu Zhongmin Z Gu Yuying Y Yu Zuoren Z
Molecular therapy. Nucleic acids 20200829
Adult hearts are hard to recover after cardiac injury due to the limited proliferative ability of cardiomyocytes. Emerging evidence indicates the induction of cell cycle reentry of cardiomyocytes by special treatment or stimulation, which offers adult heart regenerative potential. Herein, a microRNA (miRNA) screening in cardiomyocytes identified miR-301a enriched specially in the neonatal cardiomyocytes from rats and mice. Overexpression of miR-301a in primary neonatal cardiomyocytes and H9C2 ce ...[more]