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Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis


ABSTRACT: The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge. The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation. Herein, we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen (PCEI) and multifunctional PCEI-based F127-?-polypeptide-alginic (FEA) dressing (FEA-PCEI) for accelerating wound healing and hair follicle neogenesis. PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization. The FEA-PCEI dressing showed the temperature-response gelation, injectability, robust antibacterial activity, light-damage-resistant, homeostasis ability, and good cytocompatibility. The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability, reduce the scar formation, and promote the hair follicle neogenesis. This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials. Graphical abstract Image 1 Highlights • Anti-inflammation PCEI and multifunctional PCEI-based hydrogel was fabricated.• PCEI and hydrogel dressing inhibited inflammation with increased M2 macrophages.• PCEI-based hydrogel dressing showed antibacterial/anti-UV/hemostasis activity.• PCEI-based hydrogel dressing promoted wound healing and hair follicle neogenesis.

SUBMITTER: Liu W 

PROVIDER: S-EPMC7516176 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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