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The effect of prior thecal puncture on cerebrospinal fluid analytes in normal adult horses.


ABSTRACT: BACKGROUND:Serial cerebrospinal fluid (CSF) analysis might be required in clinical neurologic disease. The effect of lumbosacral (LS) or cervical (C1-C2) centesis on subsequent CSF cytologic analyses has not been investigated in horses. OBJECTIVE:To evaluate the effect of thecal puncture on subsequent CSF analyses ANIMALS: Ten healthy adult horses. METHODS:Prospective study. Horses were randomly assigned to undergo CSF collection twice, 14?days apart, from either the C1-C2 or LS space. After a 4-month washout period, CSF collection was repeated from the alternate site. Continuous data were analyzed using linear mixed-effects models and count data using mixed-effects negative binomial regression. Statistical significance was set at P?

SUBMITTER: Chidlow H 

PROVIDER: S-EPMC7517835 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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The effect of prior thecal puncture on cerebrospinal fluid analytes in normal adult horses.

Chidlow Hayley H   Giguère Steeve S   Camus Melinda M   Wells Bridgette B   Berghaus Roy R   McConachie Beasley Erin E  

Journal of veterinary internal medicine 20200702 5


<h4>Background</h4>Serial cerebrospinal fluid (CSF) analysis might be required in clinical neurologic disease. The effect of lumbosacral (LS) or cervical (C1-C2) centesis on subsequent CSF cytologic analyses has not been investigated in horses.<h4>Objective</h4>To evaluate the effect of thecal puncture on subsequent CSF analyses ANIMALS: Ten healthy adult horses.<h4>Methods</h4>Prospective study. Horses were randomly assigned to undergo CSF collection twice, 14 days apart, from either the C1-C2  ...[more]

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