Ontology highlight
ABSTRACT:
SUBMITTER: Bhaduri U
PROVIDER: S-EPMC7533350 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Bhaduri Utsa U Merla Giuseppe G
Molecular therapy. Nucleic acids 20200902
The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the game-changing capacity of TRIM8 under stress conditions against the backdrop of cell proliferation, apoptosis, and cancer, and also highlight the dualit ...[more]