Using topological data analysis and pseudo time series to infer temporal phenotypes from electronic health records.

ABSTRACT: Temporal phenotyping enables clinicians to better understand observable characteristics of a disease as it progresses. Modelling disease progression that captures interactions between phenotypes is inherently challenging. Temporal models that capture change in disease over time can identify the key features that characterize disease subtypes that underpin these trajectories. These models will enable clinicians to identify early warning signs of progression in specific sub-types and therefore to make informed decisions tailored to individual patients. In this paper, we explore two approaches to building temporal phenotypes based on the topology of data: topological data analysis and pseudo time-series. Using type 2 diabetes data, we show that the topological data analysis approach is able t

SUBMITTER: Dagliati A 

PROVIDER: S-EPMC7536308 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature