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Impact of Tablet Shape on Drug Dissolution Rate Through Immediate Released Tablets.


ABSTRACT: Purpose: The aim of this study was to evaluate the influence of the geometric shape on the dissolution rate of the domperidone, a drug model for immediate release dosage form. In this regard, a lack of sufficient information about the effective dissolution rate of the drugs regarding their shapes has made this issue an interesting subject for researchers. Methods: For this purpose, three tablet shapes, namely flat and biconvex both in a round and oblong shapes, with different four sizes were modelled for the preparation of domperidone tablet. In vitro dissolution test was accomplished using a USP dissolution apparatus II. The drug dissolution rate was assessed by calculating various dissolution parameters; e.g., dissolution efficiency (DE), mean dissolution rate (MDR), mean dissolution time (MDT), and difference and similarity factors (f1 and f2 ). Results: Regarding the disintegration time, the larger tablets showed a faster disintegration time. When the size of the tablets was smaller, the amount of released drug was significantly decreased. In addition, #9 tablets with a flat or biconvex geometry had obvious effects on the DE values. Generally, biconvex tablets had higher DE percentage than the flat tablets. Conclusion: Noticeable differences in dissolution parameters by considering the different geometric shapes play an important role in the drug release kinetics which makes a significant effect on quick onset of action in oral administration.

SUBMITTER: Molavi F 

PROVIDER: S-EPMC7539314 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Impact of Tablet Shape on Drug Dissolution Rate Through Immediate Released Tablets.

Molavi Fatima F   Hamishehkar Hamed H   Nokhodchi Ali A  

Advanced pharmaceutical bulletin 20200809 4


<b><i>Purpose:</i></b> The aim of this study was to evaluate the influence of the geometric shape on the dissolution rate of the domperidone, a drug model for immediate release dosage form. In this regard, a lack of sufficient information about the effective dissolution rate of the drugs regarding their shapes has made this issue an interesting subject for researchers. <b><i>Methods:</i></b> For this purpose, three tablet shapes, namely flat and biconvex both in a round and oblong shapes, with d  ...[more]

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