Ontology highlight
ABSTRACT:
SUBMITTER: Ju HQ
PROVIDER: S-EPMC7542157 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Ju Huai-Qiang HQ Lin Jin-Fei JF Tian Tian T Xie Dan D Xu Rui-Hua RH
Signal transduction and targeted therapy 20201007 1
Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance. NADPH homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress. Modulating t ...[more]