Ontology highlight
ABSTRACT:
SUBMITTER: Bruning JG
PROVIDER: S-EPMC7544221 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Brüning Jan-Gert JG Marians Kenneth J KJ
Nucleic acids research 20201001 18
The vast majority of the genome is transcribed by RNA polymerases. G+C-rich regions of the chromosomes and negative superhelicity can promote the invasion of the DNA by RNA to form R-loops, which have been shown to block DNA replication and promote genome instability. However, it is unclear whether the R-loops themselves are sufficient to cause this instability or if additional factors are required. We have investigated replisome collisions with transcription complexes and R-loops using a recons ...[more]