Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC7545163 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yang Long L Geng Tingting T Yang Guang G Ma Jinzhu J Wang Leilei L Ketkar Harshada H Yang Duomeng D Lin Tao T Hwang Jesse J Zhu Shu S Wang Yanlin Y Dai Jianfeng J You Fuping F Cheng Gong G Vella Anthony T AT Flavell Richard A RA Fikrig Erol E Wang Penghua P
Communications biology 20201008 1
Macrophage scavenger receptor 1 (MSR1) mediates the endocytosis of modified low-density lipoproteins and plays an important antiviral role. However, the molecular mechanism underlying MSR1 antiviral actions remains elusive. We report that MSR1 activates autophagy to restrict infection of Chikungunya virus (CHIKV), an arthritogenic alphavirus that causes acute and chronic crippling arthralgia. Msr1 expression was rapidly upregulated after CHIKV infection in mice. Msr1 knockout mice had elevated v ...[more]