Ontology highlight
ABSTRACT:
SUBMITTER: Judith D
PROVIDER: S-EPMC3674439 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
EMBO reports 20130426 6
Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52--but not its mouse orthologue--interacts with the non-structural protein nsP2, thereby promoting vi ...[more]