Unknown

Dataset Information

0

Species-specific impact of the autophagy machinery on Chikungunya virus infection.


ABSTRACT: Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52--but not its mouse orthologue--interacts with the non-structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity.

SUBMITTER: Judith D 

PROVIDER: S-EPMC3674439 | biostudies-other | 2013 Jun

REPOSITORIES: biostudies-other

altmetric image

Publications


Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52--but not its mouse orthologue--interacts with the non-structural protein nsP2, thereby promoting vi  ...[more]

Similar Datasets

| S-EPMC10290254 | biostudies-literature
| S-EPMC7545163 | biostudies-literature
| S-EPMC2874343 | biostudies-literature
2022-03-02 | GSE182287 | GEO
2015-07-07 | PXD000736 | Pride
| PRJDB7465 | ENA
| PRJNA473275 | ENA
| PRJNA668673 | ENA
| PRJNA609363 | ENA
| PRJDB8750 | ENA