Ontology highlight
ABSTRACT:
SUBMITTER: Di Rienzo L
PROVIDER: S-EPMC7548301 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Di Rienzo Lorenzo L Milanetti Edoardo E Testi Claudia C Montemiglio Linda Celeste LC Baiocco Paola P Boffi Alberto A Ruocco Giancarlo G
Computational and structural biotechnology journal 20200924
Protein-protein interactions regulate almost all cellular functions and rely on a fine tune of surface amino acids properties involved on both molecular partners. The disruption of a molecular association can be caused even by a single residue mutation, often leading to a pathological modification of a biochemical pathway. Therefore the evaluation of the effects of amino acid substitutions on binding, and the <i>ad hoc</i> design of protein-protein interfaces, is one of the biggest challenges in ...[more]