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Imaging of anticancer drug action in single cells.

ABSTRACT: Imaging is widely used in anticancer drug development, typically for whole-body tracking of labelled drugs to different organs or to assess drug efficacy through volumetric measurements. However, increasing attention has been drawn to pharmacology at the single-cell level. Diverse cell types, including cancer-associated immune cells, physicochemical features of the tumour microenvironment and heterogeneous cell behaviour all affect drug delivery, response and resistance. This Review summarizes developments in the imaging of in vivo anticancer drug action, with a focus on microscopy approaches at the single-cell level and translational lessons for the clinic.

SUBMITTER: Miller MA

PROVIDER: S-EPMC7552440 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Imaging of anticancer drug action in single cells.

Miller Miles A MA Weissleder Ralph R

Nature reviews. Cancer 20170601 7

Imaging is widely used in anticancer drug development, typically for whole-body tracking of labelled drugs to different organs or to assess drug efficacy through volumetric measurements. However, increasing attention has been drawn to pharmacology at the single-cell level. Diverse cell types, including cancer-associated immune cells, physicochemical features of the tumour microenvironment and heterogeneous cell behaviour all affect drug delivery, response and resistance. This Review summarizes d ...[more]

PMID: 28642603

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