Dataset Information

Ethnicity-Stratified Analysis of the Association between TNF-α Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Several studies have reported conflicting findings regarding the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and acute kidney injury (AKI). Therefore, we performed this meta-analysis to further investigate whether TNF-α variants are related to AKI susceptibility.

Methods

A comprehensive search of observational studies on the association of TNF-α polymorphism with AKI susceptibility was conducted in the PubMed, Cochrane, and Embase databases through February 10, 2020. Pooled odds ratios (ORs) and 95% corresponding confidence intervals (95% CIs) were analyzed to evaluate the strength of the relationship.

Results

A total of 8 studies involving 6694 patients (2559 cases and 4135 controls) were included. Pooled analysis showed a trend of increased risk between the TNF-α rs1800629 variant and AKI (A vs. G: OR [95%CI] = 1.33 [0.98-1.81]) among the overall population. Ethnicity-stratified analysis indicated that the TNF-α rs1800629 variant was a risk factor for Asians (OR [95%CI] = 1.93 [1.59-2.35]) while it is not for Caucasians (OR [95%CI] = 1.04 [0.91-1.20]). Additionally, we also found that TNF-α rs1799964 polymorphism was observed to have a significant relationship with AKI risk in Asian patients (C vs. T, OR [95%CI] = 1.26 [1.11-1.43]).

Conclusions

The TNF rs1800629 polymorphism exhibited a trend toward AKI susceptibility with ethnic differences. The relationship was found to be significant among the Asian population, but not among those of Caucasian origin. Additionally, the TNF-α rs1799964 polymorphism was also related to a significantly increased risk of AKI in Asians.

SUBMITTER: Chen G

PROVIDER: S-EPMC7556080 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Ethnicity-Stratified Analysis of the Association between TNF-<i>α</i> Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis.

Chen Guanzhong G Liu Bowen B Li Huanqiang H Mai Ziling Z Zhang Liyao L Li Min M Liu Liwei L Chen Shiqun S Chen Jiyan J Liu Yong Y

BioMed research international 20201005

<h4>Background</h4>Several studies have reported conflicting findings regarding the association between tumor necrosis factor-alpha (TNF-<i>α</i>) genetic polymorphisms and acute kidney injury (AKI). Therefore, we performed this meta-analysis to further investigate whether TNF-<i>α</i> variants are related to AKI susceptibility.<h4>Methods</h4>A comprehensive search of observational studies on the association of TNF-<i>α</i> polymorphism with AKI susceptibility was conducted in the PubMed, Cochr ...[more]

PMID: 33083469

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