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Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells.


ABSTRACT: Human colon cancer is the third leading cause of mortality in the United States and worldwide. Chemoprevention using diet is widely accepted as a promising approach for cancer management. Numerous population studies indicate a negative correlation between the incidence of colon cancer and consumption of whole grains with a high content of bioactive phenolic compounds. In the current study, we evaluated the anticancer properties of a high phenolic sorghum bran extract prepared using 70% ethanol with 5% citric acid solvent at room temperature. A significant dose-dependent suppression of cell proliferation was observed in human colon cancer cells treated with the high phenolic sorghum bran extract. Apoptosis and S phase growth arrest were induced, while cell migration and invasion were inhibited by this treatment; these effects were accompanied by altered expression of apoptosis, cell cycle, and metastasis-regulating genes. We also found that the high phenolic sorghum bran extract stimulated DNA damage in association with induction of extracellular signal-regulated kinase (ERK) and c-Jun-NH2-terminal kinase (JNK) and subsequent expression of activating transcription factor 3 (ATF3). The present study expands our understanding of the potential use of high phenolic sorghum bran to prevent human colon cancer.

SUBMITTER: Lee SH 

PROVIDER: S-EPMC7556115 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells.

Lee Seong-Ho SH   Lee Jihye J   Herald Thomas T   Cox Sarah S   Noronha Leela L   Perumal Ramasamy R   Lee Hee-Seop HS   Smolensky Dmitriy D  

Oxidative medicine and cellular longevity 20201002


Human colon cancer is the third leading cause of mortality in the United States and worldwide. Chemoprevention using diet is widely accepted as a promising approach for cancer management. Numerous population studies indicate a negative correlation between the incidence of colon cancer and consumption of whole grains with a high content of bioactive phenolic compounds. In the current study, we evaluated the anticancer properties of a high phenolic sorghum bran extract prepared using 70% ethanol w  ...[more]

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