Ontology highlight
ABSTRACT:
SUBMITTER: Niu Y
PROVIDER: S-EPMC7556866 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Niu Yiming Y Tao Xiao X Touhara Kouki K KK MacKinnon Roderick R
eLife 20200826
G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP<sub>2</sub>. Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP<sub>2</sub> concentration. We find that PIP<sub>2</sub> shifts the equilibrium between two distinguishable structures of neuronal GIRK (GIRK2), extended and docked, towards the docked form. In the docked form the cytoplasmic domain, to which G<sub>βγ ...[more]