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Mathematical model of Boltzmann’s sigmoidal equation applicable to the spreading of the coronavirus (Covid-19) waves

ABSTRACT: Currently, investigations are intensively conducted on modeling, forecasting, and studying the dynamic spread of coronavirus (Covid-19) new pandemic. In the present work, the sigmoidal-Boltzmann mathematical model was applied to study the Covid-19 spread in 15 different countries. The cumulative number of infected persons I has been accurately fitted by the sigmoidal-Boltzmann equation (SBE), giving rise to different epidemiological parameters such as the pandemic peak tp, the maximum number of infected persons Imax, and the time of the epidemic stabilization t?. The time constant relative to the sigmoid ?t (called also the slope factor) was revealed to be the determining parameter which influences all the epidemiological parameters. Empirical laws between the different parameters allowed us to propose a modified sigmoidal-Boltzmann equation describing the spread of the pandemic. The expression of the spread speed Vp was further determined as a function of the sigmoid parameters. This made it possible to assess the maximum speed of spread of the virus Vpmax and to trace the speed profile in each country. In addition, for countries undergoing a second pandemic wave, the cumulative number of infected people I has been successfully adjusted by a double sigmoidal-Boltzmann equation (DSBE) allowing the comparison between the two waves. Finally, the comparison between the maximum virus spread of two waves Vp?max?1 and Vp?max?2 showed that the intensity of the second wave of Covid-19 is low compared to the first for all the countries studied.

SUBMITTER: El Aferni A

PROVIDER: S-EPMC7557153 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Project description:Background A pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (COVID 19) incidence data are largely available online. Until August 17, COVID 19 has hit more than 22 million individuals all over the globe. So, it is urged to get clear information about the prevalence of the virus. Therefore, one can manipulate easily a suitable mathematical model to fit these published data. Methods We propose a mathematical model that considers the total population, in 25 countries, either infected by COVID 19 or confined (safe) during the period from November 17, 2019, to August 17, 2020. The model considers the total population as a complex number; the imaginary part is the number of infected individuals and the real part is the number of confined individuals. This classification combined with mathematical treatments leads to a transmission dynamics of the virus to be as wave-like motion. The virus can hit any country either by one wave or by successive waves (up to 11 waves). Findings We find net discrimination between the 25 countries investigated in this report. The immediate response to the first attack is a substantial parameter to determine whether the epidemic attack will be in one wave or it can be in successive waves. For example, the best case was such as individuals in China hit by one wave while the individuals in the USA were attacked by nine waves; it is the worst case all over the globe. In addition, the model differentiates between the daily reproduction numbers (Rd0) and the median reproduction number (R0). We have found that Rd0 decreases exponentially with time from high values down to zero at the wave maximum point; and R0 varies from a country to another. For example, the virus hit individuals in Germany in R0 = 1.39 (96% CI 1.01–3.87) and in the USA R0 = 3.81 (91% CI 1.71–5.15). We have found that twice the virus has hit both the USA and Iran. The great protestation of black matter lives in the USA and the great assemblage of the new Iranian year, on March 21, 2020, have been the cause of the second epidemic attack in both countries. Interpretation Our results show that COVID 19 transmission depends on the prompt reaction against the first viral-wave. The reaction depends on both the social behaviour of individuals and on the swift system-decision by the governmental decision-maker(s). The Chinese strictly follow the decision-maker and therefore the virus hit by only one wave; while in the USA, the system-decision was different and the American-responses were different, therefore ten waves followed the first wave. Supplementary Information The online version contains supplementary material available at 10.1186/s40001-021-00596-6.

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Mathematical model of Boltzmann’s sigmoidal equation applicable to the spreading of the coronavirus (Covid-19) waves

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