Ontology highlight
ABSTRACT:
SUBMITTER: Moyo P
PROVIDER: S-EPMC7558993 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Moyo Phanankosi P Mugumbate Grace G Eloff Jacobus N JN Louw Abraham I AI Maharaj Vinesh J VJ Birkholtz Lyn-Marié LM
Pharmaceuticals (Basel, Switzerland) 20200917 9
The ability to block human-to-mosquito and mosquito-to-human transmission of <i>Plasmodium</i> parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a transmission-blocking drug but its use is severely restricted by toxicity in some populations. New, safe and clinically effective transmission-blocking drugs therefore need to be discovered. While natural products have been extensively investigated for the development of c ...[more]