Ontology highlight
ABSTRACT:
SUBMITTER: Jeong YS
PROVIDER: S-EPMC7560051 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Jeong Yun Soo YS Lam Thuy Giang TG Jeong Seho S Ahn Sang-Gun SG
Pharmaceuticals (Basel, Switzerland) 20200828 9
Multidrug resistance is a significant clinical crisis in cancer treatment and has been linked to the cellular expression of multidrug efflux transporters. The aim of this study was to examine the effects and mechanisms of the metformin derivative HL156A on human multidrug resistance (MDR) cancer cells. Here, HL156A significantly suppressed cell growth and colony formation through G2/M phase cell cycle arrest in MDR cancer cells. HL156A also reduced the wound closure rate and cell migration and i ...[more]