Ontology highlight
ABSTRACT:
SUBMITTER: Itoh Y
PROVIDER: S-EPMC7560712 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Itoh Yuzuru Y Naschberger Andreas A Mortezaei Narges N Herrmann Johannes M JM Amunts Alexey A
Nature communications 20201014 1
Mitoribosomes are specialized protein synthesis machineries in mitochondria. However, how mRNA binds to its dedicated channel, and tRNA moves as the mitoribosomal subunit rotate with respect to each other is not understood. We report models of the translating fungal mitoribosome with mRNA, tRNA and nascent polypeptide, as well as an assembly intermediate. Nicotinamide adenine dinucleotide (NAD) is found in the central protuberance of the large subunit, and the ATPase inhibitory factor 1 (IF<sub> ...[more]