Ontology highlight
ABSTRACT:
SUBMITTER: Ivanovs A
PROVIDER: S-EPMC7561509 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Stem cell reports 20200917 4
Human hematopoietic stem cells (HSCs) emerge in the aorta-gonad-mesonephros (AGM) region during Carnegie stages (CS) 14-17. Although we previously reported that these HSCs can generate no less than 300 daughter HSCs, their actual number has never been established. Here, we show that a single human AGM region HSC can generate 600-1,600 functional daughter HSCs. The presence of HSCs in the CS 17 liver in one case gave us a unique opportunity to describe a reduction of HSC self-renewal potential af ...[more]