Ontology highlight
ABSTRACT:
SUBMITTER: Bittel DC
PROVIDER: S-EPMC7565960 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Bittel Daniel C DC Chandra Goutam G Tirunagri Laxmi M S LMS Deora Arun B AB Medikayala Sushma S Scheffer Luana L Defour Aurelia A Jaiswal Jyoti K JK
Cells 20200819 9
Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated muscle cell membrane repair in cultured muscle cells. We find that injury-triggered increase in cytosolic calcium causes AnxA2 to bind dysferlin and accumulate on dysferlin-containing v ...[more]