Ontology highlight
ABSTRACT:
SUBMITTER: Mesrouze Y
PROVIDER: S-EPMC7566471 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Mesrouze Yannick Y Aguilar Gustavo G Bokhovchuk Fedir F Martin Typhaine T Delaunay Clara C Villard Frédéric F Meyerhofer Marco M Zimmermann Catherine C Fontana Patrizia P Wille Roman R Vorherr Thomas T Erdmann Dirk D Furet Pascal P Scheufler Clemens C Schmelzle Tobias T Affolter Markus M Chène Patrick P
Scientific reports 20201015 1
The most downstream elements of the Hippo pathway, the TEAD transcription factors, are regulated by several cofactors, such as Vg/VGLL1-3. Earlier findings on human VGLL1 and here on human VGLL3 show that these proteins interact with TEAD via a conserved amino acid motif called the TONDU domain. Surprisingly, our studies reveal that the TEAD-binding domain of Drosophila Vg and of human VGLL2 is more complex and contains an additional structural element, an Ω-loop, that contributes to TEAD bindin ...[more]