Ontology highlight
ABSTRACT:
SUBMITTER: Arjuna S
PROVIDER: S-EPMC7568567 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Arjuna Srividya S Venkataram Rajesh R Dechamma Pandyanda Nanjappa PN Chakraborty Gunimala G Babu Nishith N D'Cruz Audrey A Hosmane Giridhar Belur GB Chakraborty Anirban A
Scientific reports 20201016 1
Targeting epidermal growth factor receptor (EGFR) through tyrosine kinase inhibitors (TKI) is a successful therapeutic strategy in non-small cell lung cancer. However, the response to TKI therapy depends on specific activating and acquired mutations in the tyrosine kinase domain of the EGFR gene. Therefore, confirming the EGFR status of patients is crucial, not only for determining the eligibility, but also for monitoring the emergence of mutations in patients under TKI therapy. In this study, o ...[more]