Ontology highlight
ABSTRACT:
SUBMITTER: Jasenosky LD
PROVIDER: S-EPMC7576113 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20200925 9
The human <i>TNF/LT</i> locus genes <i>TNF</i>, <i>LTA</i>, and <i>LTB</i> are expressed in a cell type-specific manner. In this study, we show that a highly conserved NFAT binding site within the distal noncoding element hHS-8 coordinately controls <i>TNF</i> and <i>LTA</i> gene expression in human T cells. Upon activation of primary human CD4<sup>+</sup> T cells, hHS-8 and the <i>TNF</i> and <i>LTA</i> promoters display increased H3K27 acetylation and nuclease sensitivity and coordinate induct ...[more]