Ontology highlight
ABSTRACT:
SUBMITTER: Demmers LC
PROVIDER: S-EPMC7577990 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Demmers Laura C LC Kretzschmar Kai K Van Hoeck Arne A Bar-Epraïm Yotam E YE van den Toorn Henk W P HWP Koomen Mandy M van Son Gijs G van Gorp Joost J Pronk Apollo A Smakman Niels N Cuppen Edwin E Clevers Hans H Heck Albert J R AJR Wu Wei W
Nature communications 20201021 1
Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte antigen (HLA) peptide ligands are promising leads to invoke targeted anti-tumor responses. Here, we investigate the variability in HLA class I peptide presentation between different clonal cells of the same colorectal cancer patient, using an organoid system. While clone-specific differences in HLA peptide presentation ...[more]