Ontology highlight
ABSTRACT:
SUBMITTER: Engelsen AST
PROVIDER: S-EPMC7578759 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Engelsen Agnete S T AST Wnuk-Lipinska Katarzyna K Bougnaud Sebastien S Pelissier Vatter Fanny A FA Tiron Crina C Villadsen René R Miyano Masaru M Lotsberg Maria L ML Madeleine Noëlly N Panahandeh Pouda P Dhakal Sushil S Tan Tuan Zea TZ Peters Stacey D'mello SD Grøndal Sturla S Aziz Sura M SM Nord Silje S Herfindal Lars L Stampfer Martha R MR Sørlie Therese T Brekken Rolf A RA Straume Oddbjørn O Halberg Nils N Gausdal Gro G Thiery Jean Paul JP Akslen Lars A LA Petersen Ole W OW LaBarge Mark A MA Lorens James B JB
iScience 20201007 11
The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of stemness traits in cancer by co-option of a regulatory function normally reserved for stem cells. AXL-expressing cells in human mammary epithelial ducts co-expressed markers associated with multipotency, and AXL inhibition abolished colony formation and self-maintenance activiti ...[more]