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High plasma salivary ?-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study.

ABSTRACT: The relationship between salivary ?-amylase activity (psAAa) or AMY1 copy number and the risk of obesity remains controversial. We aimed to assess this relationship in a cohort from Qatar, where obesity affects 43% of adults. The relationship was investigated cross-sectionally in 923 Qatari adults from the Qatar biobank cohort. AMY1 CN was estimated form whole genome sequencing data. The associations with obesity prevalence were assessed by linear and logistic regressions. We found no difference in AMY1 CN between obese and normal-weight individuals. However, the psAAa was significantly lower in obese individuals. Significant inverse correlations were found between adiposity markers and psAAa in both sexes, but were marginally stronger in men. A significant effect of high psAAa, but not AMY1 CN, on reduced obesity rates was identified in men (OR per psAAa unit 0.957 [95% CI 0.937-0.977], p?

SUBMITTER: Al-Akl N

PROVIDER: S-EPMC7578794 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study.

Al-Akl Neyla N Thompson Richard I RI Arredouani Abdelilah A

Scientific reports 20201021 1

The relationship between salivary α-amylase activity (psAAa) or AMY1 copy number and the risk of obesity remains controversial. We aimed to assess this relationship in a cohort from Qatar, where obesity affects 43% of adults. The relationship was investigated cross-sectionally in 923 Qatari adults from the Qatar biobank cohort. AMY1 CN was estimated form whole genome sequencing data. The associations with obesity prevalence were assessed by linear and logistic regressions. We found no difference ...[more]

PMID: 33087771

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| S-EPMC4489572 | biostudies-literature

Association of Serum Amylase Activity and the Copy Number Variation of <i>AMY1/2A/2B</i> with Metabolic Syndrome in Chinese Adults.

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