Ontology highlight
ABSTRACT:
SUBMITTER: Karelou M
PROVIDER: S-EPMC7582268 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Karelou Maria M Kourafalos Vasileios V Tragomalou Athanasia P AP Marakos Panagiotis P Pouli Nicole N Tsitsilonis Ourania E OE Gikas Evangelos E Kostakis Ioannis K IK
Molecules (Basel, Switzerland) 20201008 19
Several new amino-substituted aza-acridine derivatives bearing a basic side chain have been designed and synthesized. The antiproliferative activity of the target compounds has been evaluated against three cancer cell lines-namely HCT-116 (colorectal), the uterine sarcoma MES-SA, and its doxorubicin-resistant variant MES-SA/Dx5. A limited number of the new acridines showed marginal cytotoxicity against the tested cell lines; nevertheless, these analogues possessed a similar substitution pattern. ...[more]