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Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats.

ABSTRACT: Background and aim:Gastric ulcer is a chronic disease and serious health issue. Celosia trigyna is a medicinal plant used traditionally for wound healing. This study aimed to isolate the bioactive compounds from Celosia trigyna and to investigate the in vitro and in vivo anti-ulcerogenic effects of the extracts on ethanol-induced gastric ulcer on adult Wistar rats to determine their regenerative potential. Experimental procedure:Seven groups (A - negative control, B - vehicle control, C, D, E, F and G - positive control, n = 5) of five adult Wistar rats received treatment for ethanol-induced gastric ulcer. Results and conclusion:Phytochemical analysis led to the isolation of chondrillasterol, lutein, pheophytin a and chondrillasterol acetate. The in vitro results showed dichloromethane and hexane extracts to have maximum chymotrypsin inhibition relative to the standard (chymostatin) while in vivo results showed a significant increase in ulcer parameters of the vehicle control relative to groups treated with plant extracts (P < 0.05). Ulcer parameters and DNA density in groups treated with dichloromethane and hexane extracts were comparable to the negative control. Gross and histopathological findings confirmed gastric mucosa lesions in the vehicle control. There were mild ulcerations in groups treated with the ethyl acetate and methanol extracts with no observable ulcerations in the groups treated with dichloromethane and hexane extracts as the histoarchitectural outlines do not show any form of necrosis, distortion or cellular vacuolation. It was concluded that non-polar, hydrophobic compounds are able to remediate the degree of ulceration but not polar compounds.

SUBMITTER: Ofusori AE

PROVIDER: S-EPMC7588333 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Antiulcerogenic effects of <i>Celosia trigyna</i> plant extracts on ethanol-induced gastric ulcer in adult Wistar rats.

Ofusori Adebimpe Esther AE Moodley Roshila R Jonnalagadda Sreekantha B SB

Journal of traditional and complementary medicine 20191201 6

<h4>Background and aim</h4>Gastric ulcer is a chronic disease and serious health issue. <i>Celosia trigyna</i> is a medicinal plant used traditionally for wound healing. This study aimed to isolate the bioactive compounds from <i>Celosia trigyna</i> and to investigate the <i>in vitro</i> and <i>in vivo</i> anti-ulcerogenic effects of the extract<i>s</i> on ethanol-induced gastric ulcer on adult Wistar rats to determine their regenerative potential.<h4>Experimental procedure</h4>Seven groups (A - ...[more]

PMID: 33134135

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Project description:Mushrooms are nutritious foods that are widely cultivated all over the world. They are rich in a range of compounds linked to improving functions of the immune system including carotenoids, alkaloids, lectins, enzymes, folates, fats, organic acids, minerals, polysaccharides, phenolics, proteins, tocopherols, terpenoids, and volatile compounds. In this study we investigated, the immunomodulatory activity in rats of the aqueous extracts of five of the most common edible mushrooms belonging to Family Basidiomycota-white-rot fungi including, Lentinula edodes, Agaricus bisporus, Pleurotus ostreatus, Pleurotus columbinus, and Pleurotus sajor-caju. Male Wistar albino rats were assigned to thirteen groups and Immunosuppression was induced by oral administration of dexamethasone (0.1 mg/kg), followed by oral administration of the mushroom extracts at low (200 mg/kg) and high (400 mg/kg) doses. A positive control group received the immune stimulant Echinacea extract Immulant® at (30 mg/kg), while the negative control group received only saline. From each animal, in each group, blood samples were collected after 15 days for complete blood counts and for measurement of immunologic parameters, including lysozyme activity, nitric oxide (NO) production and serum cytokines including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and interleukin 1 beta (IL-1β) levels. Results have shown that white blood cells (WBCs) and lymphocytic counts were significantly boosted by high doses of each of the five mushroom extracts (207-289% increase for WBC and 153-175% for lymphocytes) with a significant increase in lysozyme activity (110-136% increase), NO concentration (159-232% increase) and cytokines as compared to the negative control group. Histopathological examination of the rats' spleen and thymus tissues has shown marked lymphocytic proliferation that was more obvious at the higher doses. In conclusion, our results showed that the five edible mushroom extracts revealed significant immunostimulatory effects preclinically particularly, at the higher doses (400 mg/kg) which can be considered the effective dose.

Dataset Information

Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats.

Publications

Antiulcerogenic effects of <i>Celosia trigyna</i> plant extracts on ethanol-induced gastric ulcer in adult Wistar rats.

Similar Datasets

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