Ontology highlight
ABSTRACT:
SUBMITTER: N Kolodkin A
PROVIDER: S-EPMC7589522 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
NPJ systems biology and applications 20201026 1
How the network around ROS protects against oxidative stress and Parkinson's disease (PD), and how processes at the minutes timescale cause disease and aging after decades, remains enigmatic. Challenging whether the ROS network is as complex as it seems, we built a fairly comprehensive version thereof which we disentangled into a hierarchy of only five simpler subnetworks each delivering one type of robustness. The comprehensive dynamic model described in vitro data sets from two independent lab ...[more]