Ontology highlight
ABSTRACT:
SUBMITTER: Bednarz A
PROVIDER: S-EPMC7589678 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Bednarz Aleksandra A Lipiński Paweł P Starzyński Rafał R RR Tomczyk Mateusz M Kraszewska Izabela I Herman Sylwia S Kowalski Kacper K Gruca Ewelina E Jończy Aneta A Mazgaj Rafał R Szudzik Mateusz M Rajfur Zenon Z Baster Zbigniew Z Józkowicz Alicja A Lenartowicz Małgorzata M
International journal of molecular sciences 20201020 20
In most mammals, neonatal intravascular hemolysis is a benign and moderate disorder that usually does not lead to anemia. During the neonatal period, kidneys play a key role in detoxification and recirculation of iron species released from red blood cells (RBC) and filtered out by glomeruli to the primary urine. Activity of heme oxygenase 1 (HO1), a heme-degrading enzyme localized in epithelial cells of proximal tubules, seems to be of critical importance for both processes. We show that, in HO1 ...[more]