Ontology highlight
ABSTRACT:
SUBMITTER: Colon-Otero G
PROVIDER: S-EPMC7592247 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Colon-Otero Gerardo G Zanfagnin Valentina V Hou Xiaonan X Foster Nathan R NR Asmus Erik J EJ Wahner Hendrickson Andrea A Jatoi Aminah A Block Matthew S MS Langstraat Carrie L CL Glaser Gretchen E GE Dinh Tri A TA Robertson Matthew W MW Camoriano John K JK Butler Kristina A KA Copland John A JA Weroha S John SJ
ESMO open 20201001 5
<h4>Objective</h4>We describe a phase II clinical trial of the combination of ribociclib and letrozole for treatment of relapsed oestrogen receptor (ER)-positive ovarian cancer (OC) and endometrial cancer (EC). The primary endpoint was the proportion of patients alive, progression-free survival (PFS), and still on treatment at 12 weeks (PFS12), with 45% or greater considered positive.<h4>Methods</h4>Patients with measurable, relapsed ER-positive OC or EC (platinum-sensitive or resistant) were el ...[more]