Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids.
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ABSTRACT:
SUBMITTER: Yao Y
PROVIDER: S-EPMC7592905 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids.
Yao Yongpeng Y An Chunyan C Evans Declan D Liu Weiwei W Wang Wei W Wei Guangzheng G Ding Ning N Houk K N KN Gao Shu-Shan SS
Journal of the American Chemical Society 20191023 44
A dedicated enzyme for the formation of the central C ring in the tetracyclic ergoline of clinically important ergot alkaloids has never been found. Herein, we report a dual role catalase (EasC), unexpectedly using O<sub>2</sub> as the oxidant, that catalyzes the oxidative cyclization of the central C ring from a 1,3-diene intermediate. Our study showcases how nature evolves the common catalase for enantioselective C-C bond construction of complex polycyclic scaffolds. ...[more]
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