Ontology highlight
ABSTRACT:
SUBMITTER: Corsi A
PROVIDER: S-EPMC7593313 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Corsi Alessandro A Palmisano Biagio B Spica Emanuela E Di Filippo Annamaria A Coletta Ilenia I Dello Spedale Venti Michele M Labella Rossella R Fabretti Francesca F Donsante Samantha S Remoli Cristina C Serafini Marta M Riminucci Mara M
Calcified tissue international 20200901 6
We compared the effects of a nitrogen-containing bisphosphonate (N-BP), zoledronic acid (ZA), and an anti-mouse RANKL antibody (anti-mRANKL Ab) on the bone tissue pathology of a transgenic mouse model of human fibrous dysplasia (FD). For comparison, we also reviewed the histological samples of a child with McCune-Albright syndrome (MAS) treated with Pamidronate for 3 years. EF1α-Gsα<sup>R201C</sup> mice with FD-like lesions in the tail vertebrae were treated with either 0.2 mg/kg of ZA at day 0, ...[more]