Ontology highlight
ABSTRACT:
SUBMITTER: Grygorenko OO
PROVIDER: S-EPMC7593547 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
iScience 20201015 11
An approach to the generation of ultra-large chemical libraries of readily accessible ("REAL") compounds is described. The strategy is based on the use of two- or three-step three-component reaction sequences and available starting materials with pre-validated chemical reactivity. After the preliminary parallel experiments, the methods with at least ∼80% synthesis success rate (such as acylation - deprotection - acylation of monoprotected diamines or amide formation - click reaction with functio ...[more]