Ontology highlight
ABSTRACT:
SUBMITTER: Bonifazi A
PROVIDER: S-EPMC7594663 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Bonifazi Alessandro A Yano Hideaki H Ellenberger Michael P MP Muller Ludovic L Kumar Vivek V Zou Mu-Fa MF Cai Ning Sheng NS Guerrero Adrian M AM Woods Amina S AS Shi Lei L Newman Amy Hauck AH
Journal of medicinal chemistry 20170316 7
The development of bivalent ligands has attracted interest as a way to potentially improve the selectivity and/or affinity for a specific receptor subtype. The ability to bind two distinct receptor binding sites simultaneously can allow the selective activation of specific G-protein dependent or β-arrestin-mediated cascade pathways. Herein, we developed an extended SAR study using sumanirole (1) as the primary pharmacophore. We found that substitutions in the N-1- and/or N-5-positions, physioche ...[more]