Ontology highlight
ABSTRACT:
SUBMITTER: Su L
PROVIDER: S-EPMC7606612 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Su Linjia L Bryan Nadezda N Battista Sabrina S Freitas Juliano J Garabedian Alyssa A D'Alessio Federica F Romano Miriam M Falanga Fabiana F Fusco Alfredo A Kos Lidia L Chambers Jeremy J Fernandez-Lima Francisco F Chapagain Prem P PP Vasile Stefan S Smith Layton L Leng Fenfei F
Scientific reports 20201102 1
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a multi-functional DNA-binding protein that plays important roles in tumorigenesis and adipogenesis. Previous results showed that HMGA2 is a potential therapeutic target of anticancer and anti-obesity drugs by inhibiting its DNA-binding activities. Here we report the development of a miniaturized, automated AlphaScreen ultra-high-throughput screening assay to identify inhibitors targeting HMGA2-DNA interactions. After screening the L ...[more]