Ontology highlight
ABSTRACT:
SUBMITTER: Abshire ET
PROVIDER: S-EPMC7606674 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Abshire Elizabeth T ET Hughes Kelsey L KL Diao Rucheng R Pearce Sarah S Gopalakrishna Shreekara S Trievel Raymond C RC Rorbach Joanna J Freddolino Peter L PL Goldstrohm Aaron C AC
The Journal of biological chemistry 20200823 44
Nocturnin (NOCT) is a eukaryotic enzyme that belongs to a superfamily of exoribonucleases, endonucleases, and phosphatases. In this study, we analyze the expression, processing, localization, and cellular functions of human NOCT. We find that NOCT protein is differentially expressed and processed in a cell and tissue type-specific manner to control its localization to the cytoplasm or mitochondrial exterior or interior. The N terminus of NOCT is necessary and sufficient to confer import and proc ...[more]