A density-based threshold model for evaluating the separation of particles in heterogeneous mixtures with curvilinear microfluidic channels.

ABSTRACT: Particle separation techniques play an important role in biomedical research. Inertial focusing based microfluidics using nonlinear channels is one of the promising label-free technologies for biological applications. The particle separation is achieved as a result of the combination of inertial lift force (F_L) and Dean drag force (F_D). Although the mathematical expressions of F_L and F_D have been well derived in prior studies, they are still complicated, which limits their popularity in practice. Recent studies modified these expressions through experiments and proposed a threshold model, which assumes that only particles larger than the threshold will be well focused. Although this threshold model has been used in recent studies, two varying ver

SUBMITTER: Chen CK 

PROVIDER: S-EPMC7643107 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature