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Integrated acoustic and magnetic separation in microfluidic channels.


ABSTRACT: With a growing number of cell-based biotechnological applications, there is a need for particle separation systems capable of multiparameter separations at high purity and throughput, beyond what is presently offered by traditional methods including fluorescence activated cell sorting and column-based magnetic separation. Toward this aim, we report on the integration of microfluidic acoustic and magnetic separation in a monolithic device for multiparameter particle separation. Using our device, we demonstrate high-purity separation of a multicomponent particle mixture at a throughput of up to 10(8) particleshr.

SUBMITTER: Adams JD 

PROVIDER: S-EPMC2807449 | biostudies-other | 2009 Dec

REPOSITORIES: biostudies-other

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